Despite numerous studies indicating that transient cerebral oxygen depletion has a detrimental effect on cognition, surprisingly little research has examined the possibility of cognitive enhancement following elevated oxygen levels in healthy adults. Here, we present evidence demonstrating that oxygen administration improves memory formation…

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https://link.springer.com/article/10.1007/BF02246665

This study attempted to identify the effect of inhalation of highly concentrated oxygen on reaction time during simple visual matching tasks. Nine right-handed male graduate students (23.0+/-1.4 years) participated in the study. Two subsets of simple visual matching tasks with similar difficulties were developed. The experiment consisted of visual matching tasks performed under two conditions: normal air (22.1% oxygen) and hyperoxic air (43.2% oxygen). There was a significant decrease in reaction time in the presence of 43.2% oxygen compared with the 22.1% oxygen condition. This result supports the hypothesis that hyperoxic air increase oxygen saturation level in the blood, lead to more available oxygen to the brain, thus increase the ability of cognitive processing.

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https://pubmed.ncbi.nlm.nih.gov/19429029/

This study investigated the effect of 30% oxygen administration on memory cognitive performance, blood oxygen saturation, and heart rate. Ten healthy male and female college students participated in the study. The experiment consisted of two runs: one was a memory task, with normal air (21% oxygen) administered and the other was with hyperoxic air (30% oxygen) administered. The experimental sequence in each run consisted of Rest (1 min), Control Task (1 min), Word Presentation (1 min), Reaction Time Task (1 min), Distractor (2 min), and Word Recall (1 min). Blood oxygen saturation and heart rate were measured throughout the six phases. The results of the memory performance analysis reveal that word recall rates were enhanced with 30% oxygen administration compared to 21% oxygen. When 30% oxygen was supplied, blood oxygen saturation was increased and heart rate was decreased compared to that with 21% oxygen administration. This result supports the hypothesis that 30% oxygen administration would lead to increases in memory performance.

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https://link.springer.com/chapter/10.1007/978-3-540-36841-0_190

Aging is characterized by the progressive loss of physiological capacity. At the cellular level, two key hallmarks of the aging process include telomere length (TL) shortening and cellular senescence. Repeated intermittent hyperoxic exposures, using certain hyperbaric oxygen therapy (HBOT) protocols, can induce regenerative effects which normally occur during hypoxia. The aim of the current study was to evaluate whether HBOT affects TL and senescent cell concentrations in a normal, non-pathological, aging adult population.

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https://www.aging-us.com/article/202188/text

The objective of the pilot study was to test the effect of inhaling 99.5% oxygen on recovery. The source of concentrated oxygen was O-PUR (Oxyfit). Research subjects completed two thirty-second Wingate tests at an interval of ten minutes, and in the interval between the tests the subjects inhaled either oxygen or a placebo in random order. This procedure was then repeated. The pilot study revealed a significantly (p<0.03) smaller performance drop in the second Wingate test following the inhalation of 99.5% oxygen when compared with the placebo. The results of the study indicate that inhaling concentrated oxygen may have a positive effect on short-term recovery processes.

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https://www.researchgate.net/publication/47369051_The_effect_of_inhaling_concentrated_oxygen_on_performance_during_repeated_anaerobic_exercise

The University of New Mexico undertook a study on maximally trained athletes to determine the effects of hyperoxic training. It was found that after 6 weeks of training with supplemental oxygen athletes attained a significant improvement in the capacity for high-intensity exercise

https://www.sciencedirect.com/science/article/abs/pii/S0012369215424468

This pioneer, proof-of-concept, double-blind study showed that normobaric oxygen treatment is beneficial in patients with depression. These results require further examination and replication in future studies of larger cohorts. Given that normobaric oxygen treatment is a simple, not invasive and safe therapeutic intervention makes it a potential and attractive treatment for depression.

https://www.nature.com/articles/s41598-021-98245-9

This study demonstrated that breathing a hyperoxic mixture with 40% O2improved the total work performed and the associated training load during an open-loop test of RSA in trained team- and racquet-sport athletes. This ergogenic effect occurred concurrent with an increase in muscle oxygenation fluxes during sprints and recovery periods and in neuromuscular activity. Although this study showed promising results about the effectiveness of mild hyperoxia to enhance TL during RSA sessions, important factors such as manipulation of FIO2and optimum exercise-to-rest ratios remain to be explored for efficient applications.

https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2022.817280/full

This study presents novel findings on performance effects and physiological responses to high-intensity interval training with hyperoxia in already trained cyclists. We showed that 6-week high-intensity interval training induced non-significant, but potentially meaningful performance gains without affecting VO2max, hematological parameters, mitochondrial oxidative phosphorylation capacity, and biomarkers of mitochondrial content in already trained cyclists.



https://pmc.ncbi.nlm.nih.gov/articles/PMC6587061/